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10.8. Absence of islet autoantibodies and modestly raised glucose values at diabetes diagnosis should Lead to testing for MODY: lessons from a 5-year pediatric Swedish National Cohort study

A Carlsson , M Shepherd , S Ellard , M Weedon , A Lernmark , G Forsander , K Colclough , Q Brahimi , C Valtonen-Andre , SA Ivarsson , H Elding Larsson , U Samuelsson , E Ortqvist , L Groop , J Ludvigsson , C Marcus , AT Hattersley

Diabetes Care. 2020; 43:8289. doi: 10.2337/dc19-0747.It is often difficult to identify maturity-onset diabetes of the young (MODY) in pediatric patients close to diabetes onset. Hence, misdiagnosis and unnecessary insulin treatment are still common.This study reports the discriminatory clinical features at diabetes onset in Swedish pediatric patients (age 118 y...

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ey0020.8-9 | New Paradigms | ESPEYB20

8.9. Elevations in blood glucose before and after the appearance of islet autoantibodies in children

K Warncke , A Weiss , P Achenbach , T von dem Berge , R Berner , K Casteels , L Groele , K Hatzikotoulas , A Hommel , O Kordonouri , H Elding Larsson , M Lundgren , BA Marcus , MD Snape , A Szypowska , JA Todd , E Bonifacio , AG Ziegler , GPPAD POInT Study Groups

Brief summary: In this longitudinal study, blood glucose trajectories and their relationship with autoantibodies appearance were assessed in 1050 children with high genetic risk of type 1 diabetes (T1D) between 4 months and 3.6 years. Post-prandial blood glucose levels increased around 2 months prior to autoantibody seroconversion, with further increases thereafter, suggesting that islet autoimmunity co-occurs or follows insults on the β-cells.This ...

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ESPE Yearbook of Paediatric Endocrinology

10.8. Absence of islet autoantibodies and modestly raised glucose values at diabetes diagnosis should Lead to testing for MODY: lessons from a 5-year pediatric Swedish National Cohort study

8.9. Elevations in blood glucose before and after the appearance of islet autoantibodies in children

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